ETF Research

XBI: STATE STREET(R) SPDR(R) S&P(R) BIOTECH ETF

Generated from StockValueFinder data · Updated Oct 11, 2026 11:24 PM
Educational content only. This is not financial advice and is not a recommendation to buy, sell, or hold any ETF.

Share-split context: A forward split was recorded on Sep 11, 2015 with coefficient 3.000003. A forward split turns each old share into multiple new shares and lowers the quoted price per share proportionally. Proportional ownership is unchanged at the split moment, so the split itself creates neither a gain nor a loss. The price-return figures in this report are already split-adjusted.

What this ETF is trying to do

The STATE STREET(R) SPDR(R) S&P(R) BIOTECH ETF (XBI) is an exchange-traded fund that invests in biotechnology companies. It holds a variety of stocks in this sector. As of October 8, 2026, the fund has 166 total holdings.

Top Holdings

The fund's portfolio can change over time. Some of its largest holdings include:

• Moderna Inc: 1.95%

• Twist Bioscience Corp: 1.84%

• Natera Inc: 1.72%

• Biogen Inc: 1.57%

• AbbVie Inc: 1.54%

What the numbers show

The current price of XBI is $150.23. Because this ETF has a history of share splits, we look at split-adjusted returns to see how it has performed.

• Price Return: This measures only the change in the share price. The one-year price return is approximately 44.90%, and the three-year price return is approximately 107.99%.

• Total Return: This reflects the overall return, including distributions. The one-year total return is approximately 45.50%, and the three-year total return is approximately 109.27%.

• Year-to-Date (YTD): The YTD price return is 23.21%, while the YTD total return is approximately 23.33%.

This ETF has a history of a "forward split" from September 11, 2015. In a forward split, each old share becomes multiple new shares, and the price per share drops proportionally. This change does not create a gain or a loss; it simply changes the number of shares an investor owns.

Income and distribution explanation

XBI provides cash distributions to investors, but they happen irregularly. Over the last 12 months, there were 2 payouts. The distribution yield is approximately 0.36%.

It is important for beginners to know that a distribution yield is not the same as a total return. While distributions provide cash income, they do not guarantee that the original investment value (the principal) will stay the same.

NAV erosion explanation

"NAV erosion" happens when the internal value of a fund's assets declines over time. StockValueFinder uses an erosion-risk score to measure this. XBI has an erosion score of 100, and the label states "No price erosion detected." The erosion severity is rated as "good," and there is no severe erosion-risk flag.

Pros

• Strong split-adjusted price and total returns over the last one and three years.

• No detected price erosion according to the erosion-risk score.

• Diversified across 166 different holdings.

Cons

• Very low distribution yield.

• Distributions are irregular and less frequent.

Beginner takeaway

XBI focuses on the biotech industry. While it has shown significant price growth over the last three years, it is not designed for investors seeking high regular income. Always remember that a high yield alone can be misleading, as it does not account for whether the share price is rising or falling.

Top Holdings

Structured portfolio holdings supplied by the ETF data provider. These figures are not generated by the AI article.

166 holdings available
# Holding Ticker Weight
1 MODERNA INC MRNA 1.95%
2 TWIST BIOSCIENCE CORP TWST 1.84%
3 NATERA INC NTRA 1.72%
4 BIOGEN INC BIIB 1.57%
5 ABBVIE INC ABBV 1.54%
6 HALOZYME THERAPEUTICS INC HALO 1.52%
7 AMGEN INC AMGN 1.51%
8 GILEAD SCIENCES INC GILD 1.51%
9 CRISPR THERAPEUTICS AG CRSP 1.49%
10 TG THERAPEUTICS INC TGTX 1.49%
Show all 166 holdings
1. MODERNA INC MRNA 1.95%
2. TWIST BIOSCIENCE CORP TWST 1.84%
3. NATERA INC NTRA 1.72%
4. BIOGEN INC BIIB 1.57%
5. ABBVIE INC ABBV 1.54%
6. HALOZYME THERAPEUTICS INC HALO 1.52%
7. AMGEN INC AMGN 1.51%
8. GILEAD SCIENCES INC GILD 1.51%
9. CRISPR THERAPEUTICS AG CRSP 1.49%
10. TG THERAPEUTICS INC TGTX 1.49%
11. SPYRE THERAPEUTICS INC SYRE 1.47%
12. INCYTE CORP INCY 1.44%
13. REGENERON PHARMACEUTICALS INC REGN 1.44%
14. VERTEX PHARMACEUTICALS INC VRTX 1.44%
15. KRYSTAL BIOTECH INC KRYS 1.43%
16. ORUKA THERAPEUTICS INC ORKA 1.43%
17. EXELIXIS INC EXEL 1.41%
18. VIKING THERAPEUTICS INC VKTX 1.41%
19. BIOMARIN PHARMACEUTICAL INC BMRN 1.40%
20. UNITED THERAPEUTICS CORP UTHR 1.40%
21. ALNYLAM PHARMACEUTICALS INC ALNY 1.39%
22. PROTAGONIST THERAPEUTICS INC PTGX 1.38%
23. MADRIGAL PHARMACEUTICALS INC MDGL 1.36%
24. ALKERMES PLC ALKS 1.35%
25. INSMED INC INSM 1.34%
26. PTC THERAPEUTICS INC PTCT 1.34%
27. REVOLUTION MEDICINES INC ORDINARY SHARES RVMD 1.34%
28. NEUROCRINE BIOSCIENCES INC NBIX 1.31%
29. TRAVERE THERAPEUTICS INC ORDINARY SHARES TVTX 1.31%
30. CYTOKINETICS INC CYTK 1.29%
31. ROIVANT SCIENCES LTD ORDINARY SHARES ROIV 1.28%
32. DIANTHUS THERAPEUTICS INC DNTH 1.27%
33. BRIDGEBIO PHARMA INC BBIO 1.26%
34. KYMERA THERAPEUTICS INC ORDINARY SHARES KYMR 1.22%
35. COGENT BIOSCIENCES INC COGT 1.21%
36. n/a PRAX 1.19%
37. ARROWHEAD PHARMACEUTICALS INC ARWR 1.18%
38. ERASCA INC ERAS 1.15%
39. RHYTHM PHARMACEUTICALS INC RYTM 1.15%
40. IONIS PHARMACEUTICALS INC IONS 1.14%
41. IOVANCE BIOTHERAPEUTICS INC IOVA 1.13%
42. CG ONCOLOGY INC CGON 1.11%
43. VAXCYTE INC ORDINARY SHARES PCVX 1.11%
44. MIRUM PHARMACEUTICALS INC MIRM 1.08%
45. GRAIL INC GRAL 1.05%
46. VERACYTE INC VCYT 1.01%
47. IMMUNITYBIO INC ORDINARY SHARES IBRX 0.99%
48. TANGO THERAPEUTICS INC TNGX 0.98%
49. CELCUITY INC CELC 0.94%
50. SCHOLAR ROCK HOLDING CORP SRRK 0.89%
51. RELAY THERAPEUTICS INC ORDINARY SHARES RLAY 0.86%
52. UNIQURE NV QURE 0.85%
53. BEAM THERAPEUTICS INC BEAM 0.83%
54. HYPERLIQUID STRATEGIES INC PURR 0.82%
55. n/a ARQT 0.78%
56. ULTRAGENYX PHARMACEUTICAL INC RARE 0.75%
57. IMMUNOVANT INC IMVT 0.72%
58. CAREDX INC CDNA 0.71%
59. DYNE THERAPEUTICS INC ORDINARY SHARES DYN 0.69%
60. SELLAS LIFE SCIENCES GROUP INC SLS 0.64%
61. ACADIA PHARMACEUTICALS INC ACAD 0.62%
62. DENALI THERAPEUTICS INC DNLI 0.62%
63. RECURSION PHARMACEUTICALS INC CLASS A RXRX 0.60%
64. VERA THERAPEUTICS INC CLASS A VERA 0.60%
65. IDEAYA BIOSCIENCES INC IDYA 0.59%
66. SUMMIT THERAPEUTICS INC ORDINARY SHARES SMMT 0.59%
67. BIOCRYST PHARMACEUTICALS INC BCRX 0.58%
68. AGIOS PHARMACEUTICALS INC AGIO 0.57%
69. NEKTAR THERAPEUTICS NKTR 0.55%
70. SAREPTA THERAPEUTICS INC SRPT 0.55%
71. ARCUS BIOSCIENCES INC RCUS 0.54%
72. PALVELLA THERAPEUTICS INC PVLA 0.53%
73. VIRIDIAN THERAPEUTICS INC VRDN 0.53%
74. INTELLIA THERAPEUTICS INC NTLA 0.52%
75. NURIX THERAPEUTICS INC ORDINARY SHARES NRIX 0.52%
76. BIOHAVEN LTD BHVN 0.50%
77. CELLDEX THERAPEUTICS INC CLDX 0.49%
78. NOVAVAX INC NVAX 0.48%
79. ABSCI CORP ABSI 0.47%
80. DISC MEDICINE INC ORDINARY SHARES IRON 0.47%
81. IMMUNOME INC ORDINARY SHARES IMNM 0.47%
82. SYNDAX PHARMACEUTICALS INC SNDX 0.44%
83. ADMA BIOLOGICS INC ADMA 0.43%
84. PRECIGEN INC PGEN 0.42%
85. VERICEL CORP VCEL 0.42%
86. KODIAK SCIENCES INC KOD 0.40%
87. MINERALYS THERAPEUTICS INC MLYS 0.39%
88. STOKE THERAPEUTICS INC STOK 0.34%
89. ANAPTYSBIO INC ANAB 0.32%
90. FIRST TRACKS BIOTHERAPEUTICS INC TRAX 0.32%
91. INHIBRX BIOSCIENCES INC INBX 0.32%
92. ORIC PHARMACEUTICALS INC ORIC 0.32%
93. REPLIMUNE GROUP INC REPL 0.32%
94. XENCOR INC XNCR 0.31%
95. ZENAS BIOPHARMA INC ZBIO 0.30%
96. KURA ONCOLOGY INC KURA 0.28%
97. VIR BIOTECHNOLOGY INC VIR 0.28%
98. ARRIVENT BIOPHARMA INC AVBP 0.27%
99. TYRA BIOSCIENCES INC TYRA 0.26%
100. ARDELYX INC ARDX 0.25%
101. JADE BIOSCIENCES INC JBIO 0.25%
102. MONTE ROSA THERAPEUTICS INC GLUE 0.25%
103. n/a TSHA 0.25%
104. CANDEL THERAPEUTICS INC CADL 0.24%
105. IMMIX BIOPHARMA INC IMMX 0.24%
106. MANNKIND CORP MNKD 0.24%
107. ANNEXON INC ORDINARY SHARES ANNX 0.22%
108. AVALO THERAPEUTICS INC AVTX 0.22%
109. BICARA THERAPEUTICS INC BCAX 0.22%
110. CORVUS PHARMACEUTICALS INC CRVS 0.22%
111. GERON CORP GERN 0.22%
112. RIGEL PHARMACEUTICALS INC RIGL 0.22%
113. VOR BIOPHARMA INC ORDINARY SHARES VOR 0.21%
114. CULLINAN THERAPEUTICS INC CGEM 0.20%
115. HEMAB THERAPEUTICS HOLDINGS INC COAG 0.19%
116. n/a OLMA 0.19%
117. JANUX THERAPEUTICS INC ORDINARY SHARES JANX 0.18%
118. VERASTEM INC VSTM 0.18%
119. n/a FDMT 0.17%
120. SANA BIOTECHNOLOGY INC ORDINARY SHARES SANA 0.17%
121. ACHIEVE LIFE SCIENCES INC ACHV 0.16%
122. KAILERA THERAPEUTICS INC KLRA 0.16%
123. SAVARA INC SVRA 0.16%
124. ALLOGENE THERAPEUTICS INC ALLO 0.15%
125. CAPRICOR THERAPEUTICS INC CAPR 0.15%
126. DAMORA THERAPEUTICS INC ORDINARY SHARES DMRA 0.15%
127. REGENXBIO INC RGNX 0.15%
128. ALTIMMUNE INC ALT 0.14%
129. CYTOMX THERAPEUTICS INC CTMX 0.14%
130. IRONWOOD PHARMACEUTICALS INC CLASS A IRWD 0.14%
131. SOLID BIOSCIENCES INC SLDB 0.14%
132. ARBUTUS BIOPHARMA CORP ABUS 0.13%
133. CLIMB BIO INC CLYM 0.13%
134. SAGIMET BIOSCIENCES INC ORDINARY SHARES SERIES A SGMT 0.13%
135. MONOPAR THERAPEUTICS INC MNPR 0.12%
136. CABALETTA BIO INC ORDINARY SHARES CABA 0.11%
137. DESIGN THERAPEUTICS INC DSGN 0.11%
138. EDITAS MEDICINE INC EDIT 0.11%
139. EMERGENT BIOSOLUTIONS INC EBS 0.11%
140. MYRIAD GENETICS INC MYGN 0.11%
141. OCUGEN INC OCGN 0.11%
142. PRIME MEDICINE INC PRME 0.11%
143. SHATTUCK LABS INC ORDINARY SHARES STTK 0.11%
144. AKTIS ONCOLOGY INC AKTS 0.10%
145. ARS PHARMACEUTICALS INC SPRY 0.09%
146. VANDA PHARMACEUTICALS INC VNDA 0.09%
147. MIMEDX GROUP INC MDXG 0.08%
148. NEUROGENE INC NGNE 0.08%
149. PROTHENA CORP PLC PRTA 0.08%
150. ASSEMBLY BIOSCIENCES INC ASMB 0.07%
151. CONTRA METSERA INC COMMON STOCK n/a 0.07%
152. FAETH THERAPEUTICS INC ORDINARY SHARES FTH 0.07%
153. OVID THERAPEUTICS INC OVID 0.07%
154. AURA BIOSCIENCES INC AURA 0.06%
155. COMPASS THERAPEUTICS INC ORDINARY SHARES CMPX 0.06%
156. CRESCENT BIOPHARMA INC CBIO 0.05%
157. LEXEO THERAPEUTICS INC LXEO 0.05%
158. SSI US GOV MONEY MARKET CLASS STATE STREET INST US GOV n/a 0.04%
159. BRIDGEBIO ONCOLOGY THERAPEUTICS INC BBOT 0.03%
160. CONTRA AKERO THERAPEUT COMMON STOCK n/a 0.01%
161. CONTRA INHIBRX INC COMMON STOCK n/a 0.01%
162. CONTRA MIRATI THERAPEU COMMON STOCK n/a 0.01%
163. CONTRA VERVE THERAPEUT COMMON STOCK n/a 0.01%
164. CONTRA BLUEPRINT MEDIC COMMON STOCK n/a 0.00%
165. OMNIAB INC 12.5 EARNOUT COMMON STOCK n/a 0.00%
166. OMNIAB INC 15.00 EARNOUT COMMON STOCK n/a 0.00%
Holdings data last updated Oct 8, 2026 5:15 AM .
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