1.
VERTEX PHARMACEUTICALS INC
VRTX
8.14%
2.
AMGEN INC
AMGN
7.93%
3.
GILEAD SCIENCES INC
GILD
7.80%
4.
REGENERON PHARMACEUTICALS INC
REGN
5.40%
5.
MODERNA INC
MRNA
3.91%
6.
REVOLUTION MEDICINES INC ORDINARY SHARES
RVMD
2.82%
7.
ILLUMINA INC
ILMN
2.35%
8.
ALNYLAM PHARMACEUTICALS INC
ALNY
2.16%
9.
BIOGEN INC
BIIB
2.16%
10.
ROIVANT SCIENCES LTD ORDINARY SHARES
ROIV
1.93%
11.
ARGENX SE ADR
ARGX
1.84%
12.
INSMED INC
INSM
1.80%
13.
ROYALTY PHARMA PLC CLASS A
RPRX
1.75%
14.
INCYTE CORP
INCY
1.69%
15.
GUARDANT HEALTH INC
GH
1.57%
16.
UNITED THERAPEUTICS CORP
UTHR
1.43%
17.
VIATRIS INC
VTRS
1.34%
18.
MEDPACE HOLDINGS INC
MEDP
1.19%
19.
ASCENDIS PHARMA AS
ASND
1.03%
20.
JAZZ PHARMACEUTICALS PLC
JAZZ
1.03%
21.
NEUROCRINE BIOSCIENCES INC
NBIX
1.02%
22.
EXELIXIS INC
EXEL
0.97%
23.
BRIDGEBIO PHARMA INC
BBIO
0.91%
24.
SUMMIT THERAPEUTICS INC ORDINARY SHARES
SMMT
0.91%
25.
HALOZYME THERAPEUTICS INC
HALO
0.87%
26.
BIOMARIN PHARMACEUTICAL INC
BMRN
0.85%
27.
MADRIGAL PHARMACEUTICALS INC
MDGL
0.83%
28.
TEMPUS AI INC CLASS A COMMON STOCK
TEM
0.83%
29.
BEONE MEDICINES LTD ADR
ONC
0.78%
30.
BIONTECH SE ADR
BNTX
0.75%
31.
AXSOME THERAPEUTICS INC
AXSM
0.74%
32.
KRYSTAL BIOTECH INC
KRYS
0.67%
33.
SANOFI SA ADR
SNY
0.67%
34.
KYMERA THERAPEUTICS INC ORDINARY SHARES
KYMR
0.65%
35.
CYTOKINETICS INC
CYTK
0.64%
36.
ARROWHEAD PHARMACEUTICALS INC
ARWR
0.63%
37.
PROTAGONIST THERAPEUTICS INC
PTGX
0.62%
38.
TWIST BIOSCIENCE CORP
TWST
0.60%
39.
n/a
TXG
0.58%
40.
n/a
PRAX
0.58%
41.
VAXCYTE INC ORDINARY SHARES
PCVX
0.57%
42.
IMMUNITYBIO INC ORDINARY SHARES
IBRX
0.56%
43.
CARIS LIFE SCIENCES INC
CAI
0.54%
44.
SPYRE THERAPEUTICS INC
SYRE
0.54%
45.
ALKERMES PLC
ALKS
0.52%
46.
IMMUNOVANT INC
IMVT
0.51%
47.
IONIS PHARMACEUTICALS INC
IONS
0.50%
48.
RHYTHM PHARMACEUTICALS INC
RYTM
0.45%
49.
CG ONCOLOGY INC
CGON
0.44%
50.
ABIVAX SA ADR
ABVX
0.40%
51.
MIRUM PHARMACEUTICALS INC
MIRM
0.40%
52.
SCHOLAR ROCK HOLDING CORP
SRRK
0.40%
53.
TRAVERE THERAPEUTICS INC ORDINARY SHARES
TVTX
0.40%
54.
n/a
AMRX
0.39%
55.
COGENT BIOSCIENCES INC
COGT
0.38%
56.
ORUKA THERAPEUTICS INC
ORKA
0.38%
57.
PTC THERAPEUTICS INC
PTCT
0.38%
58.
LIGAND PHARMACEUTICALS INC
LGND
0.37%
59.
XENON PHARMACEUTICALS INC
XENE
0.37%
60.
CRISPR THERAPEUTICS AG
CRSP
0.34%
61.
EDGEWISE THERAPEUTICS INC
EWTX
0.33%
62.
ACADIA PHARMACEUTICALS INC
ACAD
0.32%
63.
ERASCA INC
ERAS
0.32%
64.
ADAPTIVE BIOTECHNOLOGIES CORP
ADPT
0.30%
65.
IOVANCE BIOTHERAPEUTICS INC
IOVA
0.30%
66.
n/a
DFTX
0.28%
67.
n/a
INDV
0.28%
68.
RELAY THERAPEUTICS INC ORDINARY SHARES
RLAY
0.27%
69.
AMYLYX PHARMACEUTICALS INC
AMLX
0.25%
70.
ABCELLERA BIOLOGICS INC ORDINARY SHARES
ABCL
0.24%
71.
n/a
KNSA
0.24%
72.
n/a
TARS
0.23%
73.
TANGO THERAPEUTICS INC
TNGX
0.23%
74.
DENALI THERAPEUTICS INC
DNLI
0.22%
75.
GRAIL INC
GRAL
0.22%
76.
IDEAYA BIOSCIENCES INC
IDYA
0.22%
77.
n/a
ARQT
0.22%
78.
VERACYTE INC
VCYT
0.21%
79.
ENLIVEN THERAPEUTICS INC
ELVN
0.20%
80.
MBX BIOSCIENCES INC
MBX
0.20%
81.
DYNE THERAPEUTICS INC ORDINARY SHARES
DYN
0.19%
82.
STRUCTURE THERAPEUTICS INC ADR
GPCR
0.19%
83.
DISC MEDICINE INC ORDINARY SHARES
IRON
0.18%
84.
GENMAB AS ADR
GMAB
0.18%
85.
NURIX THERAPEUTICS INC ORDINARY SHARES
NRIX
0.18%
86.
PHARVARIS NV ORDINARY SHARES
PHVS
0.18%
87.
PRECIGEN INC
PGEN
0.18%
88.
UNIQURE NV
QURE
0.18%
89.
n/a
HRMY
0.17%
90.
NEWAMSTERDAM PHARMA CO NV
NAMS
0.17%
91.
BEAM THERAPEUTICS INC
BEAM
0.16%
92.
SUPERNUS PHARMACEUTICALS INC
SUPN
0.16%
93.
AURINIA PHARMACEUTICALS INC
AUPH
0.15%
94.
MINERALYS THERAPEUTICS INC
MLYS
0.15%
95.
OCULAR THERAPEUTIX INC
OCUL
0.15%
96.
VERA THERAPEUTICS INC CLASS A
VERA
0.15%
97.
ADMA BIOLOGICS INC
ADMA
0.14%
98.
BIOCRYST PHARMACEUTICALS INC
BCRX
0.14%
99.
KODIAK SCIENCES INC
KOD
0.14%
100.
SAREPTA THERAPEUTICS INC
SRPT
0.14%
101.
TREVI THERAPEUTICS INC
TRVI
0.14%
102.
UROGEN PHARMA LTD
n/a
0.14%
103.
VERICEL CORP
VCEL
0.14%
104.
ZENAS BIOPHARMA INC
ZBIO
0.14%
105.
AGIOS PHARMACEUTICALS INC
AGIO
0.13%
106.
FORTREA HOLDINGS INC
FTRE
0.13%
107.
GH RESEARCH PLC
GHRS
0.13%
108.
NOVOCURE LTD
NVCR
0.13%
109.
RAPPORT THERAPEUTICS INC
RAPP
0.13%
110.
ZYMEWORKS INC REGISTERED SHS
ZYME
0.13%
111.
COMPASS PATHWAYS PLC ADR
CMPS
0.12%
112.
SEPTERNA INC
SEPN
0.12%
113.
STOKE THERAPEUTICS INC
STOK
0.12%
114.
VIR BIOTECHNOLOGY INC
VIR
0.12%
115.
XENCOR INC
XNCR
0.12%
116.
ALVOTECH
ALVO
0.11%
117.
ANAPTYSBIO INC
ANAB
0.11%
118.
ANI PHARMACEUTICALS INC
ANIP
0.11%
119.
INNOVIVA INC
INVA
0.11%
120.
INTELLIA THERAPEUTICS INC
NTLA
0.11%
121.
PERSONALIS INC
PSNL
0.11%
122.
RECURSION PHARMACEUTICALS INC CLASS A
RXRX
0.11%
123.
BICARA THERAPEUTICS INC
BCAX
0.10%
124.
ETON PHARMACEUTICALS INC
ETON
0.10%
125.
INHIBRX BIOSCIENCES INC
INBX
0.10%
126.
INVESCO SHRT-TRM INV GOV&AGCY INSTL
AGPXX
0.10%
127.
LEGEND BIOTECH CORP ADR
LEGN
0.10%
128.
n/a
TSHA
0.10%
129.
NOVAVAX INC
NVAX
0.10%
130.
SYNDAX PHARMACEUTICALS INC
SNDX
0.10%
131.
TYRA BIOSCIENCES INC
TYRA
0.10%
132.
ARRIVENT BIOPHARMA INC
AVBP
0.09%
133.
CULLINAN THERAPEUTICS INC
CGEM
0.09%
134.
FIRST TRACKS BIOTHERAPEUTICS INC
TRAX
0.09%
135.
HARROW INC
HROW
0.09%
136.
IMMUNOCORE HOLDINGS PLC ADR
IMCR
0.09%
137.
MAZE THERAPEUTICS INC
MAZE
0.09%
138.
OMEROS CORP
OMER
0.09%
139.
ORIC PHARMACEUTICALS INC
ORIC
0.09%
140.
ULTRAGENYX PHARMACEUTICAL INC
RARE
0.09%
141.
XERIS BIOPHARMA HOLDINGS INC
XERS
0.09%
142.
ABSCI CORP
ABSI
0.08%
143.
MEIRAGTX HOLDINGS PLC
MGTX
0.08%
144.
VOR BIOPHARMA INC ORDINARY SHARES
VOR
0.08%
145.
ALUMIS INC
ALMS
0.07%
146.
AMPHASTAR PHARMACEUTICALS INC
AMPH
0.07%
147.
ARBUTUS BIOPHARMA CORP
ABUS
0.07%
148.
CASTLE BIOSCIENCES INC
CSTL
0.07%
149.
CORVUS PHARMACEUTICALS INC
CRVS
0.07%
150.
JANUX THERAPEUTICS INC ORDINARY SHARES
JANX
0.07%
151.
KURA ONCOLOGY INC
KURA
0.07%
152.
MANNKIND CORP
MNKD
0.07%
153.
MONTE ROSA THERAPEUTICS INC
GLUE
0.07%
154.
n/a
MRVI
0.07%
155.
PACIRA BIOSCIENCES INC
PCRX
0.07%
156.
REPLIMUNE GROUP INC
REPL
0.07%
157.
SAVARA INC
SVRA
0.07%
158.
ARDELYX INC
ARDX
0.06%
159.
CANDEL THERAPEUTICS INC
CADL
0.06%
160.
GERON CORP
GERN
0.06%
161.
GRIFOLS SA ADR
GRFS
0.06%
162.
n/a
OLMA
0.06%
163.
RIGEL PHARMACEUTICALS INC
RIGL
0.06%
164.
SANA BIOTECHNOLOGY INC ORDINARY SHARES
SANA
0.06%
165.
SOLID BIOSCIENCES INC
SLDB
0.06%
166.
THERAVANCE BIOPHARMA INC
TBPH
0.06%
167.
WAVE LIFE SCIENCES INC
WVE
0.06%
168.
ACLARIS THERAPEUTICS INC
ACRS
0.05%
169.
AURA BIOSCIENCES INC
AURA
0.05%
170.
COLLEGIUM PHARMACEUTICAL INC
COLL
0.05%
171.
DESIGN THERAPEUTICS INC
DSGN
0.05%
172.
IRONWOOD PHARMACEUTICALS INC CLASS A
IRWD
0.05%
173.
MESOBLAST LTD ADR
MESO
0.05%
174.
n/a
FDMT
0.05%
175.
PHIBRO ANIMAL HEALTH CORP CLASS A
PAHC
0.05%
176.
ZAI LAB LTD ADR REPR 1 SHS
ZLAB
0.05%
177.
ZEVRA THERAPEUTICS INC
ZVRA
0.05%
178.
ALLOGENE THERAPEUTICS INC
ALLO
0.04%
179.
ALTIMMUNE INC
ALT
0.04%
180.
ANNEXON INC ORDINARY SHARES
ANNX
0.04%
181.
AQUESTIVE THERAPEUTICS INC
AQST
0.04%
182.
ARVINAS INC
ARVN
0.04%
183.
CORMEDIX INC
CRMD
0.04%
184.
CYTOMX THERAPEUTICS INC
CTMX
0.04%
185.
EVOLUS INC
EOLS
0.04%
186.
n/a
PHAT
0.04%
187.
n/a
SGMT
0.04%
188.
NEUROGENE INC
NGNE
0.04%
189.
OMNIAB INC
OABI
0.04%
190.
PRIME MEDICINE INC
PRME
0.04%
191.
SILENCE THERAPEUTICS PLC ADR
SLN
0.04%
192.
TECTONIC THERAPEUTIC INC
TECX
0.04%
193.
ALPHA TEKNOVA INC
TKNO
0.03%
194.
ARCTURUS THERAPEUTICS HOLDINGS INC
ARCT
0.03%
195.
ARS PHARMACEUTICALS INC
SPRY
0.03%
196.
ATEA PHARMACEUTICALS INC ORDINARY SHARES
AVIR
0.03%
197.
AUTOLUS THERAPEUTICS PLC ADR
AUTL
0.03%
198.
C4 THERAPEUTICS INC ORDINARY SHARES
CCCC
0.03%
199.
CABALETTA BIO INC ORDINARY SHARES
CABA
0.03%
200.
EDITAS MEDICINE INC
EDIT
0.03%
201.
ENANTA PHARMACEUTICALS INC
ENTA
0.03%
202.
KAMADA LTD
n/a
0.03%
203.
KYVERNA THERAPEUTICS INC
KYTX
0.03%
204.
LAKEFRONT BIOTHERAPEUTICS NV ADR
LKFT
0.03%
205.
LARIMAR THERAPEUTICS INC
LRMR
0.03%
206.
n/a
CTNM
0.03%
207.
ORCHESTRA BIOMED HOLDINGS INC
OBIO
0.03%
208.
PACIFIC BIOSCIENCES OF CALIFORNIA INC
PACB
0.03%
209.
PROTHENA CORP PLC
PRTA
0.03%
210.
PUMA BIOTECHNOLOGY INC
PBYI
0.03%
211.
REGENXBIO INC
RGNX
0.03%
212.
ROCKET PHARMACEUTICALS INC
RCKT
0.03%
213.
AC IMMUNE SA
ACIU
0.02%
214.
ANAVEX LIFE SCIENCES CORP
AVXL
0.02%
215.
BIOAGE LABS INC
BIOA
0.02%
216.
ENTRADA THERAPEUTICS INC
TRDA
0.02%
217.
EYEPOINT INC
EYPT
0.02%
218.
FOGHORN THERAPEUTICS INC ORDINARY SHARES
FHTX
0.02%
219.
FULCRUM THERAPEUTICS INC
FULC
0.02%
220.
IMMUNEERING CORP CLASS A
IMRX
0.02%
221.
INVIVYD INC ORDINARY SHARES
IVVD
0.02%
222.
LEXEO THERAPEUTICS INC
LXEO
0.02%
223.
LYELL IMMUNOPHARMA INC ORDINARY SHARES
LYEL
0.02%
224.
PYXIS ONCOLOGY INC
PYXS
0.02%
225.
SIGA TECHNOLOGIES INC
SIGA
0.02%
226.
SIONNA THERAPEUTICS INC
SION
0.02%
227.
UPSTREAM BIO INC
UPB
0.02%
228.
VANDA PHARMACEUTICALS INC
VNDA
0.02%
229.
AARDVARK THERAPEUTICS INC
AARD
0.01%
230.
BICYCLE THERAPEUTICS PLC ADR
BCYC
0.01%
231.
CARIBOU BIOSCIENCES INC ORDINARY SHARES
CRBU
0.01%
232.
CASH
n/a
0.01%
233.
CODEXIS INC
CDXS
0.01%
234.
COHERUS ONCOLOGY INC
CHRS
0.01%
235.
HUMACYTE INC
HUMA
0.01%
236.
JYONG BIOTECH LTD
MENS
0.01%
237.
KEROS THERAPEUTICS INC
KROS
0.01%
238.
LENZ THERAPEUTICS INC
LENZ
0.01%
239.
LIFECORE BIOMEDICAL INC
LFCR
0.01%
240.
n/a
BDTX
0.01%
241.
NEUMORA THERAPEUTICS INC
NMRA
0.01%
242.
NOVABRIDGE BIOSCIENCES ADR
NBP
0.01%
243.
PEPGEN INC
PEPG
0.01%
244.
QUANTUM-SI INC ORDINARY SHARES CLASS A
QSI
0.01%
245.
RANI THERAPEUTICS HOLDINGS INC CLASS A
RANI
0.01%
246.
TENAYA THERAPEUTICS INC
TNYA
0.01%
247.
VOYAGER THERAPEUTICS INC
VYGR
0.01%
248.
CARTESIAN THERAPEUTICS ([WTS/RTS]) 0%
n/a
0.00%
249.
CONTRA ADR CENTESSA
n/a
0.00%
250.
CONTRA ESPERION THERAP
n/a
0.00%
251.
GOSSAMER BIO INC
GOSS
0.00%
252.
NOVOB DC CVR
n/a
0.00%
253.
OMNIAB
n/a
0.00%
254.
SECURITIES LENDING BNYM
n/a
0.00%
255.
THIRD HARMONIC BIO INC
n/a
0.00%